A large variety of 1,3,4 substituted oxadiazoles have been found to possess anti-inflammatory, antimicrobial and antitubercular activities. A number of 1,3,4 substituted oxadiazole derivatives have been synthesized and tested for their antimicrobial activities. The chemical structures of the newly synthesized compounds were characterized via IR, 1HNMR and elemental analysis. The compounds synthesized were evaluated for their antimicrobial activity against Gram-positive bacteria (Bacillus subtilis, Staphylococcus aureus), Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa) and fungi (Penicillium notatum, Aspergillus niger, Candida albicans and Aspergillus fumigatus) by well plate method. Ciprofloxacin and ketoconazole were used as standard for bacteria and fungi respectively. The results of preliminary biological tests showed that of these compounds possess good antimicrobial activities with known standard drugs.
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